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SMILES: CN(C)c1cc2C(=O)N(C[C@@H](F)C(C)(C)O)Cc2cc1NC(=O)c1cccc(n1)C(F)(F)F

InChI Key: InChIKey=CDJXXQBQNHWVKS-QGZVFWFLSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 480668   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM480668
PNG
(N-[6-(dimethylamino)-1-oxo- 2-[rac-(2R)-2-fluoro-3...)
Show SMILES CN(C)c1cc2C(=O)N(C[C@@H](F)C(C)(C)O)Cc2cc1NC(=O)c1cccc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C22H24F4N4O3/c1-21(2,33)17(23)11-30-10-12-8-15(16(29(3)4)9-13(12)20(30)32)28-19(31)14-6-5-7-18(27-14)22(24,25)26/h5-9,17,33H,10-11H2,1-4H3,(H,28,31)/t17-/m1/s1
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PC cid
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US Patent
 1.10n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
Kinase activities were assayed using the Transcreener-Fluorecescence polarization platform (BelBrook Labs, Madison, Wis., USA) that measures amounts ...

US Patent US10899772 (2021)


BindingDB Entry DOI: 10.7270/Q2CC13SR
More data for this
Ligand-Target Pair