null
SMILES: CC(C)(Nc1ncc(cn1)C(=O)N1CCC2(C1)CCOCC2)c1cncnc1
InChI Key: InChIKey=AJNRTFNIQNDYTE-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pantetheinase (Homo sapiens (Human)) | BDBM480929 (8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[2-(pyrimidin-5-y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0820 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description The test inhibitors were solubilized in DMSO to a stock concentration of 30 mM. On the day of the assay, dose response plates were prepared by diluti... | US Patent US10906888 (2021) BindingDB Entry DOI: 10.7270/Q2QN69WB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Biotinidase (Homo sapiens) | BDBM480929 (8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[2-(pyrimidin-5-y...) | MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of N-terminal FLAG/His6-tagged human biotinidase expressed in COS cells using biotinyl-7-amino-4-trifluoromethylcoumarin as substrate prei... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01849 BindingDB Entry DOI: 10.7270/Q2XD15K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pantetheinase (Homo sapiens (Human)) | BDBM480929 (8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[2-(pyrimidin-5-y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01849 BindingDB Entry DOI: 10.7270/Q2XD15K6 | |||||||||||
More data for this Ligand-Target Pair |