BDBM482374 US10919852, Compound TABLE 1.73

SMILES: Cc1c(OCCCN2C3CCC2CC(O)C3)cccc1-c1cccc2[C@H](CCc12)Oc1cc(OCc2cncc(c2)C#N)c(CNCC2CCC(=O)N2)cc1Cl

InChI Key: InChIKey=QINLGDWTMRBSFU-RFWUFOLRSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 482374   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Programmed cell death protein 1 (Homo sapiens)	BDBM482374 (US10919852, Compound TABLE 1.73) Show SMILES Cc1c(OCCCN2C3CCC2CC(O)C3)cccc1-c1cccc2[C@H](CCc12)Oc1cc(OCc2cncc(c2)C#N)c(CNCC2CCC(=O)N2)cc1Cl |r| Show InChI InChI=1S/C45H50ClN5O5/c1-28-36(5-3-8-41(28)54-16-4-15-51-33-10-11-34(51)20-35(52)19-33)37-6-2-7-39-38(37)12-13-42(39)56-44-21-43(55-27-30-17-29(22-47)23-48-24-30)31(18-40(44)46)25-49-26-32-9-14-45(53)50-32/h2-3,5-8,17-18,21,23-24,32-35,42,49,52H,4,9-16,19-20,25-27H2,1H3,(H,50,53)/t32?,33?,34?,35?,42-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
ChemoCentryx, Inc. US Patent					Assay Description 96 Well plates were coated with 1 g/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with 2% BSA in PBS (W...				US Patent US10919852 (2021)
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