null

SMILES: OC1CCN(CCCOc2cccc(c2Cl)-c2cccc3[C@H](CCc23)Oc2cc(OCc3cncc(c3)C#N)c(CNCC3CCC(=O)N3)cc2Cl)CC1

InChI Key: InChIKey=SMXMESIUBGLCMR-AZPJNPSPSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482378   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Programmed cell death 1 ligand 1 (Homo sapiens (Human))	BDBM482378 (US10919852, Compound TABLE 1.77 | US11708326, Comp...) Show SMILES OC1CCN(CCCOc2cccc(c2Cl)-c2cccc3[C@H](CCc23)Oc2cc(OCc3cncc(c3)C#N)c(CNCC3CCC(=O)N3)cc2Cl)CC1 |r| Show InChI InChI=1S/C42H45Cl2N5O5/c43-36-19-29(24-47-25-30-8-11-41(51)48-30)39(53-26-28-18-27(21-45)22-46-23-28)20-40(36)54-37-10-9-33-32(4-1-5-34(33)37)35-6-2-7-38(42(35)44)52-17-3-14-49-15-12-31(50)13-16-49/h1-2,4-7,18-20,22-23,30-31,37,47,50H,3,8-17,24-26H2,(H,48,51)/t30?,37-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q22N56DJ
					More data for this Ligand-Target Pair
Programmed cell death protein 1 (Homo sapiens)	BDBM482378 (US10919852, Compound TABLE 1.77 | US11708326, Comp...) Show SMILES OC1CCN(CCCOc2cccc(c2Cl)-c2cccc3[C@H](CCc23)Oc2cc(OCc3cncc(c3)C#N)c(CNCC3CCC(=O)N3)cc2Cl)CC1 |r| Show InChI InChI=1S/C42H45Cl2N5O5/c43-36-19-29(24-47-25-30-8-11-41(51)48-30)39(53-26-28-18-27(21-45)22-46-23-28)20-40(36)54-37-10-9-33-32(4-1-5-34(33)37)35-6-2-7-38(42(35)44)52-17-3-14-49-15-12-31(50)13-16-49/h1-2,4-7,18-20,22-23,30-31,37,47,50H,3,8-17,24-26H2,(H,48,51)/t30?,37-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
ChemoCentryx, Inc. US Patent					Assay Description 96 Well plates were coated with 1 g/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with 2% BSA in PBS (W...				US Patent US10919852 (2021) BindingDB Entry DOI: 10.7270/Q2RF5Z3R
					More data for this Ligand-Target Pair