BDBM482383 US10919852, Compound TABLE 1.82

SMILES: Cc1c(OCCCN2CCC(O)CC2)cccc1-c1cccc2[C@@H](Oc3cc(OCc4cncc(c4)C#N)c(CN[C@@](C)(CO)C(O)=O)cc3Cl)[C@@H](F)Cc12

InChI Key: InChIKey=CFFSQKRYYVGMST-BXRZTGGSSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 482383   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Programmed cell death protein 1 (Homo sapiens)	BDBM482383 (US10919852, Compound TABLE 1.82) Show SMILES Cc1c(OCCCN2CCC(O)CC2)cccc1-c1cccc2[C@@H](Oc3cc(OCc4cncc(c4)C#N)c(CN[C@@](C)(CO)C(O)=O)cc3Cl)[C@@H](F)Cc12 |r| Show InChI InChI=1S/C42H46ClFN4O7/c1-26-31(6-4-9-37(26)53-15-5-12-48-13-10-30(50)11-14-48)32-7-3-8-33-34(32)18-36(44)40(33)55-39-19-38(54-24-28-16-27(20-45)21-46-22-28)29(17-35(39)43)23-47-42(2,25-49)41(51)52/h3-4,6-9,16-17,19,21-22,30,36,40,47,49-50H,5,10-15,18,23-25H2,1-2H3,(H,51,52)/t36-,40+,42-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
ChemoCentryx, Inc. US Patent					Assay Description 96 Well plates were coated with 1 g/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with 2% BSA in PBS (W...				US Patent US10919852 (2021)
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