BDBM482405 US10919852, Compound TABLE 1.104

SMILES: C[C@@](CO)(NCc1cc(Cl)c(O[C@H]2[C@@H](F)Cc3c2cccc3-c2cccc(OCCCN3CC(O)C3)c2Cl)cc1OCc1cc(cc(c1)C#N)C#N)C(O)=O

InChI Key: InChIKey=BPRQWVLBMOUGMR-GCQACAPMSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 482405   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Programmed cell death protein 1 (Homo sapiens)	BDBM482405 (US10919852, Compound TABLE 1.104) Show SMILES C[C@@](CO)(NCc1cc(Cl)c(O[C@H]2[C@@H](F)Cc3c2cccc3-c2cccc(OCCCN3CC(O)C3)c2Cl)cc1OCc1cc(cc(c1)C#N)C#N)C(O)=O |r| Show InChI InChI=1S/C41H39Cl2FN4O7/c1-41(23-49,40(51)52)47-19-27-14-33(42)37(16-36(27)54-22-26-12-24(17-45)11-25(13-26)18-46)55-39-31-7-2-5-29(32(31)15-34(39)44)30-6-3-8-35(38(30)43)53-10-4-9-48-20-28(50)21-48/h2-3,5-8,11-14,16,28,34,39,47,49-50H,4,9-10,15,19-23H2,1H3,(H,51,52)/t34-,39+,41-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
ChemoCentryx, Inc. US Patent					Assay Description 96 Well plates were coated with 1 g/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with 2% BSA in PBS (W...				US Patent US10919852 (2021)
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