BDBM482436 US10919852, Compound TABLE 1.135

SMILES: CC(CO)(NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2cccc(OCCCN3CC4(CC(O)C4)C3)c2Cl)cc1OCc1cncc(c1)C#N)C(O)=O

InChI Key: InChIKey=MIBLMHLDIMLKHZ-GXPRHQJDSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 482436   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Programmed cell death protein 1 (Homo sapiens)	BDBM482436 (US10919852, Compound TABLE 1.135) Show SMILES CC(CO)(NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2cccc(OCCCN3CC4(CC(O)C4)C3)c2Cl)cc1OCc1cncc(c1)C#N)C(O)=O |r| Show InChI InChI=1S/C42H44Cl2N4O7/c1-41(25-49,40(51)52)47-21-28-14-34(43)38(15-37(28)54-22-27-13-26(18-45)19-46-20-27)55-35-10-9-31-30(5-2-6-32(31)35)33-7-3-8-36(39(33)44)53-12-4-11-48-23-42(24-48)16-29(50)17-42/h2-3,5-8,13-15,19-20,29,35,47,49-50H,4,9-12,16-17,21-25H2,1H3,(H,51,52)/t35-,41?/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
ChemoCentryx, Inc. US Patent					Assay Description 96 Well plates were coated with 1 g/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with 2% BSA in PBS (W...				US Patent US10919852 (2021)
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