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SMILES: C[C@@H](O)[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2cccc(OCCCN3CC(O)C3)c2Cl)cc1OCc1cncc(c1)C#N)C(=O)NS(C)(=O)=O

InChI Key: InChIKey=FGRCYMMKRBXSNO-FQKMOEHMSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 482442   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Programmed cell death protein 1


(Homo sapiens)		BDBM482442
PNG
(US10919852, Compound TABLE 1.141)
Show SMILES C[C@@H](O)[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2cccc(OCCCN3CC(O)C3)c2Cl)cc1OCc1cncc(c1)C#N)C(=O)NS(C)(=O)=O |r|
Show InChI InChI=1S/C40H43Cl2N5O8S/c1-24(48)39(40(50)46-56(2,51)52)45-20-27-15-33(41)37(16-36(27)54-23-26-14-25(17-43)18-44-19-26)55-34-11-10-30-29(6-3-7-31(30)34)32-8-4-9-35(38(32)42)53-13-5-12-47-21-28(49)22-47/h3-4,6-9,14-16,18-19,24,28,34,39,45,48-49H,5,10-13,20-23H2,1-2H3,(H,46,50)/t24-,34+,39+/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 g/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with 2% BSA in PBS (W...

US Patent US10919852 (2021)

More data for this
Ligand-Target Pair