null

SMILES: Cc1c(OCCCN2CCC(C)(F)CC2)cccc1-c1cccc2[C@H](CCc12)Oc1cc(OCc2cncc(c2)C#N)c(CNC2CCC(=O)NC2)cc1Cl

InChI Key: InChIKey=SLBQFKPSSNUWGE-JQKQRDFRSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 482556   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Programmed cell death protein 1 (Homo sapiens)	BDBM482556 (US10919852, Compound TABLE 1.255 | US10919852, Com...) Show SMILES Cc1c(OCCCN2CCC(C)(F)CC2)cccc1-c1cccc2[C@H](CCc12)Oc1cc(OCc2cncc(c2)C#N)c(CNC2CCC(=O)NC2)cc1Cl |r| Show InChI InChI=1S/C44H49ClFN5O4/c1-29-34(6-4-9-39(29)53-19-5-16-51-17-14-44(2,46)15-18-51)35-7-3-8-37-36(35)11-12-40(37)55-42-22-41(54-28-31-20-30(23-47)24-48-25-31)32(21-38(42)45)26-49-33-10-13-43(52)50-27-33/h3-4,6-9,20-22,24-25,33,40,49H,5,10-19,26-28H2,1-2H3,(H,50,52)/t33?,40-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
ChemoCentryx, Inc. US Patent					Assay Description 96 Well plates were coated with 1 g/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with 2% BSA in PBS (W...				US Patent US10919852 (2021) BindingDB Entry DOI: 10.7270/Q2RF5Z3R
					More data for this Ligand-Target Pair
Programmed cell death 1 ligand 1 (Homo sapiens (Human))	BDBM482556 (US10919852, Compound TABLE 1.255 | US10919852, Com...) Show SMILES Cc1c(OCCCN2CCC(C)(F)CC2)cccc1-c1cccc2[C@H](CCc12)Oc1cc(OCc2cncc(c2)C#N)c(CNC2CCC(=O)NC2)cc1Cl |r| Show InChI InChI=1S/C44H49ClFN5O4/c1-29-34(6-4-9-39(29)53-19-5-16-51-17-14-44(2,46)15-18-51)35-7-3-8-37-36(35)11-12-40(37)55-42-22-41(54-28-31-20-30(23-47)24-48-25-31)32(21-38(42)45)26-49-33-10-13-43(52)50-27-33/h3-4,6-9,20-22,24-25,33,40,49H,5,10-19,26-28H2,1-2H3,(H,50,52)/t33?,40-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	253	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q22N56DJ
					More data for this Ligand-Target Pair
Programmed cell death 1 ligand 1 (Homo sapiens (Human))	BDBM482556 (US10919852, Compound TABLE 1.255 | US10919852, Com...) Show SMILES Cc1c(OCCCN2CCC(C)(F)CC2)cccc1-c1cccc2[C@H](CCc12)Oc1cc(OCc2cncc(c2)C#N)c(CNC2CCC(=O)NC2)cc1Cl |r| Show InChI InChI=1S/C44H49ClFN5O4/c1-29-34(6-4-9-39(29)53-19-5-16-51-17-14-44(2,46)15-18-51)35-7-3-8-37-36(35)11-12-40(37)55-42-22-41(54-28-31-20-30(23-47)24-48-25-31)32(21-38(42)45)26-49-33-10-13-43(52)50-27-33/h3-4,6-9,20-22,24-25,33,40,49H,5,10-19,26-28H2,1-2H3,(H,50,52)/t33?,40-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q22N56DJ
					More data for this Ligand-Target Pair
Programmed cell death protein 1 (Homo sapiens)	BDBM482556 (US10919852, Compound TABLE 1.255 | US10919852, Com...) Show SMILES Cc1c(OCCCN2CCC(C)(F)CC2)cccc1-c1cccc2[C@H](CCc12)Oc1cc(OCc2cncc(c2)C#N)c(CNC2CCC(=O)NC2)cc1Cl |r| Show InChI InChI=1S/C44H49ClFN5O4/c1-29-34(6-4-9-39(29)53-19-5-16-51-17-14-44(2,46)15-18-51)35-7-3-8-37-36(35)11-12-40(37)55-42-22-41(54-28-31-20-30(23-47)24-48-25-31)32(21-38(42)45)26-49-33-10-13-43(52)50-27-33/h3-4,6-9,20-22,24-25,33,40,49H,5,10-19,26-28H2,1-2H3,(H,50,52)/t33?,40-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	253	n/a	n/a	n/a	n/a	n/a	n/a
ChemoCentryx, Inc. US Patent					Assay Description 96 Well plates were coated with 1 g/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with 2% BSA in PBS (W...				US Patent US10919852 (2021) BindingDB Entry DOI: 10.7270/Q2RF5Z3R
					More data for this Ligand-Target Pair