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BDBM482600 US10919852, Compound TABLE 1.299

SMILES: CC(C)N1CCC(COc2cccc(c2Cl)-c2cccc3[C@H](CCc23)Oc2cc(OCc3cncc(c3)C#N)c(CNC[C@@H]3CCC(=O)N3)cc2Cl)C1

InChI Key: InChIKey=HOHNDZNYQNIBLF-CNYBHTQJSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 482600   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Programmed cell death protein 1


(Homo sapiens)		BDBM482600
PNG
(US10919852, Compound TABLE 1.299)
Show SMILES CC(C)N1CCC(COc2cccc(c2Cl)-c2cccc3[C@H](CCc23)Oc2cc(OCc3cncc(c3)C#N)c(CNC[C@@H]3CCC(=O)N3)cc2Cl)C1 |r|
Show InChI InChI=1S/C42H45Cl2N5O4/c1-26(2)49-14-13-27(23-49)24-51-38-8-4-7-35(42(38)44)32-5-3-6-34-33(32)10-11-37(34)53-40-17-39(52-25-29-15-28(18-45)19-46-20-29)30(16-36(40)43)21-47-22-31-9-12-41(50)48-31/h3-8,15-17,19-20,26-27,31,37,47H,9-14,21-25H2,1-2H3,(H,48,50)/t27?,31-,37-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
96 Well plates were coated with 1 g/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with 2% BSA in PBS (W...

US Patent US10919852 (2021)

More data for this
Ligand-Target Pair