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SMILES: CCCCOc1nc(N)c2nc(O)n(Cc3cnc(CNCc4ccncc4)cn3)c2n1

InChI Key: InChIKey=DRXGBRRZJDVMPG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 483317   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-6 (Homo sapiens (Human))	BDBM483317 (US10919895, Compound Ia-01) Show SMILES CCCCOc1nc(N)c2nc(O)n(Cc3cnc(CNCc4ccncc4)cn3)c2n1 Show InChI InChI=1S/C21H25N9O2/c1-2-3-8-32-20-28-18(22)17-19(29-20)30(21(31)27-17)13-16-12-25-15(11-26-16)10-24-9-14-4-6-23-7-5-14/h4-7,11-12,24H,2-3,8-10,13H2,1H3,(H,27,31)(H2,22,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Compounds diluted in DMSO were transferred to individual wells of a Matrix Technologies clear, V-bottom 384-well plate using ECHO acoustic liquid han...				US Patent US10919895 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM483317 (US10919895, Compound Ia-01) Show SMILES CCCCOc1nc(N)c2nc(O)n(Cc3cnc(CNCc4ccncc4)cn3)c2n1 Show InChI InChI=1S/C21H25N9O2/c1-2-3-8-32-20-28-18(22)17-19(29-20)30(21(31)27-17)13-16-12-25-15(11-26-16)10-24-9-14-4-6-23-7-5-14/h4-7,11-12,24H,2-3,8-10,13H2,1H3,(H,27,31)(H2,22,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	330	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...				US Patent US10919895 (2021)
					More data for this Ligand-Target Pair