null

SMILES: CCCCOc1nc(N)c2nc(O)n(Cc3ccc(CNCc4ccccc4)cn3)c2n1

InChI Key: InChIKey=OGJBRJWIZNSCLX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 483334   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-6 (Homo sapiens (Human))	BDBM483334 (US10919895, Compound Ib-06) Show SMILES CCCCOc1nc(N)c2nc(O)n(Cc3ccc(CNCc4ccccc4)cn3)c2n1 Show InChI InChI=1S/C23H27N7O2/c1-2-3-11-32-22-28-20(24)19-21(29-22)30(23(31)27-19)15-18-10-9-17(14-26-18)13-25-12-16-7-5-4-6-8-16/h4-10,14,25H,2-3,11-13,15H2,1H3,(H,27,31)(H2,24,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	190	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Compounds diluted in DMSO were transferred to individual wells of a Matrix Technologies clear, V-bottom 384-well plate using ECHO acoustic liquid han...				US Patent US10919895 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM483334 (US10919895, Compound Ib-06) Show SMILES CCCCOc1nc(N)c2nc(O)n(Cc3ccc(CNCc4ccccc4)cn3)c2n1 Show InChI InChI=1S/C23H27N7O2/c1-2-3-11-32-22-28-20(24)19-21(29-22)30(23(31)27-19)15-18-10-9-17(14-26-18)13-25-12-16-7-5-4-6-8-16/h4-10,14,25H,2-3,11-13,15H2,1H3,(H,27,31)(H2,24,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...				US Patent US10919895 (2021)
					More data for this Ligand-Target Pair