null
SMILES: COC\C=C\C(=O)N1CCCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
InChI Key: InChIKey=OEXJPOPQZBWMNU-FNNXTJRKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM484651![]() ((E)-4-(8-amino-3-(1- (4-methoxybut-2- enoyl)azepan...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Src enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Src enzyme (M... | US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Fyn (Homo sapiens (Human)) | BDBM484651![]() ((E)-4-(8-amino-3-(1- (4-methoxybut-2- enoyl)azepan...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description FynT enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.FynT enzyme ... | US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM484651![]() ((E)-4-(8-amino-3-(1- (4-methoxybut-2- enoyl)azepan...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M... | US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM484651![]() ((E)-4-(8-amino-3-(1- (4-methoxybut-2- enoyl)azepan...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Btk enzyme (H... | US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM484651![]() ((E)-4-(8-amino-3-(1- (4-methoxybut-2- enoyl)azepan...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme B.V. US Patent | Assay Description Lyn enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lyn enzyme (M... | US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2 | |||||||||||
More data for this Ligand-Target Pair |