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SMILES: C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1ccccc1Cl

InChI Key: InChIKey=SUTYMQMXIOGJQL-VWLOTQADSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 486379   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))		BDBM486379
PNG
(3-(2-chlorophenyl)-1-(5-fluoropyridin- 2-yl)-N-(3-...)
Show SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ccc(F)cn3)c2c1)-c1ccccc1Cl |r|
Show InChI InChI=1S/C25H21ClFN3O3S/c1-25(10-11-34(32,33)15-25)29-24(31)16-6-8-19-20(18-4-2-3-5-21(18)26)14-30(22(19)12-16)23-9-7-17(27)13-28-23/h2-9,12-14H,10-11,15H2,1H3,(H,29,31)/t25-/m0/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 9.80n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...

US Patent US10947222 (2021)

More data for this
Ligand-Target Pair