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SMILES: COC(=O)c1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1

InChI Key: InChIKey=OFIYHPAOTJVMMG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 486401   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))		BDBM486401
PNG
(US10947222, Example 32 | methyl 3-{6-[(1,1- dioxid...)
Show SMILES COC(=O)c1cccc(c1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C27H23FN2O5S/c1-35-27(32)19-4-2-3-17(13-19)24-15-30(22-8-6-20(28)7-9-22)25-14-18(5-10-23(24)25)26(31)29-21-11-12-36(33,34)16-21/h2-10,13-15,21H,11-12,16H2,1H3,(H,29,31)
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antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 3.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...

US Patent US10947222 (2021)

More data for this
Ligand-Target Pair