BDBM486416 3-(3-cyclopropylphenyl)-N-(1,1- dioxidotetrahydrothiophen-3-yl)- 1-(4-fluorophenyl)-1H-indole-6- carboxamide (racemic)::US10947222, Example 46
SMILES: Fc1ccc(cc1)-n1cc(-c2cccc(c2)C2CC2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1
InChI Key: InChIKey=VHQNWZCNGIIOEN-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human)) | BDBM486416![]() (3-(3-cyclopropylphenyl)-N-(1,1- dioxidotetrahydrot...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m... | US Patent US10947222 (2021) | |||||||||||
More data for this Ligand-Target Pair |