BDBM487703 N-(5-chloro-6-(4-methyl-2H- 1,2,3-triazol-2-yl)pyridin-3-yl)- 1-(quinolin-5-yl)-5- (trifluoromethyl)-1H-pyrazole-4- carboxamide::US10954214, Compound 125

SMILES: Cc1cnn(n1)-c1ncc(NC(=O)c2cnn(c2C(F)(F)F)-c2cccc3ncccc23)cc1Cl

InChI Key: InChIKey=GCOMSHVHNYXRJM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 487703   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487703 (N-(5-chloro-6-(4-methyl-2H- 1,2,3-triazol-2-yl)pyr...) Show SMILES Cc1cnn(n1)-c1ncc(NC(=O)c2cnn(c2C(F)(F)F)-c2cccc3ncccc23)cc1Cl Show InChI InChI=1S/C22H14ClF3N8O/c1-12-9-30-34(32-12)20-16(23)8-13(10-28-20)31-21(35)15-11-29-33(19(15)22(24,25)26)18-6-2-5-17-14(18)4-3-7-27-17/h2-11H,1H3,(H,31,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021)
					More data for this Ligand-Target Pair