BDBM487705 N-(5-chloro-6-(oxazol-2- yl)pyridin-3-yl)-1-(1-oxo-1,2- dihydroisoquinolin-5-yl)-5- (trifluoromethyl)-1H-pyrazole-4- carboxamide::US10954214, Compound 127

SMILES: FC(F)(F)c1c(cnn1-c1cccc2c1cc[nH]c2=O)C(=O)Nc1cnc(-c2ncco2)c(Cl)c1

InChI Key: InChIKey=DKBKESMECAJABJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 487705   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487705 (N-(5-chloro-6-(oxazol-2- yl)pyridin-3-yl)-1-(1-oxo...) Show SMILES FC(F)(F)c1c(cnn1-c1cccc2c1cc[nH]c2=O)C(=O)Nc1cnc(-c2ncco2)c(Cl)c1 Show InChI InChI=1S/C22H12ClF3N6O3/c23-15-8-11(9-29-17(15)21-28-6-7-35-21)31-20(34)14-10-30-32(18(14)22(24,25)26)16-3-1-2-13-12(16)4-5-27-19(13)33/h1-10H,(H,27,33)(H,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021)
					More data for this Ligand-Target Pair