null

SMILES: CCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@H](N(C)Cc2[nH]1)C(=O)N1CC(C1)N(C)C

InChI Key: InChIKey=LVJFCJHEDIELRT-QWEPBSKHSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 488299   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM488299 (US10954237, Example 8-2) Show SMILES CCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@H](N(C)Cc2[nH]1)C(=O)N1CC(C1)N(C)C |r| Show InChI InChI=1S/C28H30FN7O2/c1-5-15-9-25(37)20(29)10-19(15)16-6-7-18-21(8-16)32-33-26(18)27-30-22-11-24(35(4)14-23(22)31-27)28(38)36-12-17(13-36)34(2)3/h6-10,17,24,37H,5,11-14H2,1-4H3/b27-26-/t24-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				US Patent US10954237 (2021) BindingDB Entry DOI: 10.7270/Q2571G33
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM488299 (US10954237, Example 8-2) Show SMILES CCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@H](N(C)Cc2[nH]1)C(=O)N1CC(C1)N(C)C |r| Show InChI InChI=1S/C28H30FN7O2/c1-5-15-9-25(37)20(29)10-19(15)16-6-7-18-21(8-16)32-33-26(18)27-30-22-11-24(35(4)14-23(22)31-27)28(38)36-12-17(13-36)34(2)3/h6-10,17,24,37H,5,11-14H2,1-4H3/b27-26-/t24-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				US Patent US10954237 (2021) BindingDB Entry DOI: 10.7270/Q2571G33
					More data for this Ligand-Target Pair