null

SMILES: NS(=O)(=O)c1ccc(Cc2cn(nc2-c2cccc(OCc3ccccn3)c2)-c2nc(cs2)C(O)=O)cc1

InChI Key: InChIKey=FDUIVDAUBFHRSL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 489086   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
L-lactate dehydrogenase A chain (Homo sapiens (Human))	BDBM489086 (2-(3-(3-(pyridin-3- ylmethoxy)phenyl)-4- (4-sulfam...) Show SMILES NS(=O)(=O)c1ccc(Cc2cn(nc2-c2cccc(OCc3ccccn3)c2)-c2nc(cs2)C(O)=O)cc1 Show InChI InChI=1S/C26H21N5O5S2/c27-38(34,35)22-9-7-17(8-10-22)12-19-14-31(26-29-23(16-37-26)25(32)33)30-24(19)18-4-3-6-21(13-18)36-15-20-5-1-2-11-28-20/h1-11,13-14,16H,12,15H2,(H,32,33)(H2,27,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; VANDERBILT UNIVERSITY; THE UAB RESEARCH FOUNDATION; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA US Patent					Assay Description Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...				US Patent US10961200 (2021) BindingDB Entry DOI: 10.7270/Q2474DZ9
					More data for this Ligand-Target Pair
L-lactate dehydrogenase A chain (Homo sapiens (Human))	BDBM489086 (2-(3-(3-(pyridin-3- ylmethoxy)phenyl)-4- (4-sulfam...) Show SMILES NS(=O)(=O)c1ccc(Cc2cn(nc2-c2cccc(OCc3ccccn3)c2)-c2nc(cs2)C(O)=O)cc1 Show InChI InChI=1S/C26H21N5O5S2/c27-38(34,35)22-9-7-17(8-10-22)12-19-14-31(26-29-23(16-37-26)25(32)33)30-24(19)18-4-3-6-21(13-18)36-15-20-5-1-2-11-28-20/h1-11,13-14,16H,12,15H2,(H,32,33)(H2,27,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of LDHA in human MIA PaCa2 cells assessed as reduction in lactate production incubated for 2 hrs by fluorescence based assay				Citation and Details Article DOI: 10.1016/j.bmcl.2021.127974 BindingDB Entry DOI: 10.7270/Q24J0JV6
					More data for this Ligand-Target Pair
L-lactate dehydrogenase A chain (Homo sapiens (Human))	BDBM489086 (2-(3-(3-(pyridin-3- ylmethoxy)phenyl)-4- (4-sulfam...) Show SMILES NS(=O)(=O)c1ccc(Cc2cn(nc2-c2cccc(OCc3ccccn3)c2)-c2nc(cs2)C(O)=O)cc1 Show InChI InChI=1S/C26H21N5O5S2/c27-38(34,35)22-9-7-17(8-10-22)12-19-14-31(26-29-23(16-37-26)25(32)33)30-24(19)18-4-3-6-21(13-18)36-15-20-5-1-2-11-28-20/h1-11,13-14,16H,12,15H2,(H,32,33)(H2,27,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...				Citation and Details Article DOI: 10.1016/j.bmcl.2021.127974 BindingDB Entry DOI: 10.7270/Q24J0JV6
					More data for this Ligand-Target Pair