null

SMILES: C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCN(C)C2=O)nc1C

InChI Key: InChIKey=KVKANZTYGYFKQY-INIZCTEOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489231   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM489231 (2-[(1S)-1-Cyclopropylethyl]-5-(4-methyl-2-{[6-(3-m...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCN(C)C2=O)nc1C |r| Show InChI InChI=1S/C27H30N6O4S2/c1-15-24(38-26(28-15)30-21-6-5-7-22(29-21)32-11-10-31(3)27(32)35)18-12-19-14-33(16(2)17-8-9-17)25(34)23(19)20(13-18)39(4,36)37/h5-7,12-13,16-17H,8-11,14H2,1-4H3,(H,28,29,30)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM489231 (2-[(1S)-1-Cyclopropylethyl]-5-(4-methyl-2-{[6-(3-m...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCN(C)C2=O)nc1C |r| Show InChI InChI=1S/C27H30N6O4S2/c1-15-24(38-26(28-15)30-21-6-5-7-22(29-21)32-11-10-31(3)27(32)35)18-12-19-14-33(16(2)17-8-9-17)25(34)23(19)20(13-18)39(4,36)37/h5-7,12-13,16-17H,8-11,14H2,1-4H3,(H,28,29,30)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.71E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM489231 (2-[(1S)-1-Cyclopropylethyl]-5-(4-methyl-2-{[6-(3-m...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCN(C)C2=O)nc1C |r| Show InChI InChI=1S/C27H30N6O4S2/c1-15-24(38-26(28-15)30-21-6-5-7-22(29-21)32-11-10-31(3)27(32)35)18-12-19-14-33(16(2)17-8-9-17)25(34)23(19)20(13-18)39(4,36)37/h5-7,12-13,16-17H,8-11,14H2,1-4H3,(H,28,29,30)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [144-1102] (Homo sapiens (Human))	BDBM489231 (2-[(1S)-1-Cyclopropylethyl]-5-(4-methyl-2-{[6-(3-m...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCN(C)C2=O)nc1C |r| Show InChI InChI=1S/C27H30N6O4S2/c1-15-24(38-26(28-15)30-21-6-5-7-22(29-21)32-11-10-31(3)27(32)35)18-12-19-14-33(16(2)17-8-9-17)25(34)23(19)20(13-18)39(4,36)37/h5-7,12-13,16-17H,8-11,14H2,1-4H3,(H,28,29,30)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair