null

SMILES: C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCNC2=O)nc1C

InChI Key: InChIKey=DMIIPYYADLDKAX-HNNXBMFYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489232   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM489232 (2-[(1S)-1-Cyclopropylethyl]-5-(4-methyl-2-{[6-(2-o...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCNC2=O)nc1C |r| Show InChI InChI=1S/C26H28N6O4S2/c1-14-23(37-25(28-14)30-20-5-4-6-21(29-20)31-10-9-27-26(31)34)17-11-18-13-32(15(2)16-7-8-16)24(33)22(18)19(12-17)38(3,35)36/h4-6,11-12,15-16H,7-10,13H2,1-3H3,(H,27,34)(H,28,29,30)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM489232 (2-[(1S)-1-Cyclopropylethyl]-5-(4-methyl-2-{[6-(2-o...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCNC2=O)nc1C |r| Show InChI InChI=1S/C26H28N6O4S2/c1-14-23(37-25(28-14)30-20-5-4-6-21(29-20)31-10-9-27-26(31)34)17-11-18-13-32(15(2)16-7-8-16)24(33)22(18)19(12-17)38(3,35)36/h4-6,11-12,15-16H,7-10,13H2,1-3H3,(H,27,34)(H,28,29,30)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	219	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM489232 (2-[(1S)-1-Cyclopropylethyl]-5-(4-methyl-2-{[6-(2-o...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCNC2=O)nc1C |r| Show InChI InChI=1S/C26H28N6O4S2/c1-14-23(37-25(28-14)30-20-5-4-6-21(29-20)31-10-9-27-26(31)34)17-11-18-13-32(15(2)16-7-8-16)24(33)22(18)19(12-17)38(3,35)36/h4-6,11-12,15-16H,7-10,13H2,1-3H3,(H,27,34)(H,28,29,30)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [144-1102] (Homo sapiens (Human))	BDBM489232 (2-[(1S)-1-Cyclopropylethyl]-5-(4-methyl-2-{[6-(2-o...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCNC2=O)nc1C |r| Show InChI InChI=1S/C26H28N6O4S2/c1-14-23(37-25(28-14)30-20-5-4-6-21(29-20)31-10-9-27-26(31)34)17-11-18-13-32(15(2)16-7-8-16)24(33)22(18)19(12-17)38(3,35)36/h4-6,11-12,15-16H,7-10,13H2,1-3H3,(H,27,34)(H,28,29,30)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair