null

SMILES: C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCOCC2=O)nc1C

InChI Key: InChIKey=VLRSVMBPXWKSNE-INIZCTEOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489234   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM489234 (2-[(1S)-1-Cyclopropylethyl]-5-(4-methyl-2-{[6-(3-o...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCOCC2=O)nc1C |r| Show InChI InChI=1S/C27H29N5O5S2/c1-15-25(38-27(28-15)30-21-5-4-6-22(29-21)31-9-10-37-14-23(31)33)18-11-19-13-32(16(2)17-7-8-17)26(34)24(19)20(12-18)39(3,35)36/h4-6,11-12,16-17H,7-10,13-14H2,1-3H3,(H,28,29,30)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM489234 (2-[(1S)-1-Cyclopropylethyl]-5-(4-methyl-2-{[6-(3-o...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCOCC2=O)nc1C |r| Show InChI InChI=1S/C27H29N5O5S2/c1-15-25(38-27(28-15)30-21-5-4-6-22(29-21)31-9-10-37-14-23(31)33)18-11-19-13-32(16(2)17-7-8-17)26(34)24(19)20(12-18)39(3,35)36/h4-6,11-12,16-17H,7-10,13-14H2,1-3H3,(H,28,29,30)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	688	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM489234 (2-[(1S)-1-Cyclopropylethyl]-5-(4-methyl-2-{[6-(3-o...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCOCC2=O)nc1C |r| Show InChI InChI=1S/C27H29N5O5S2/c1-15-25(38-27(28-15)30-21-5-4-6-22(29-21)31-9-10-37-14-23(31)33)18-11-19-13-32(16(2)17-7-8-17)26(34)24(19)20(12-18)39(3,35)36/h4-6,11-12,16-17H,7-10,13-14H2,1-3H3,(H,28,29,30)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [144-1102] (Homo sapiens (Human))	BDBM489234 (2-[(1S)-1-Cyclopropylethyl]-5-(4-methyl-2-{[6-(3-o...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCOCC2=O)nc1C |r| Show InChI InChI=1S/C27H29N5O5S2/c1-15-25(38-27(28-15)30-21-5-4-6-22(29-21)31-9-10-37-14-23(31)33)18-11-19-13-32(16(2)17-7-8-17)26(34)24(19)20(12-18)39(3,35)36/h4-6,11-12,16-17H,7-10,13-14H2,1-3H3,(H,28,29,30)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair