null

SMILES: C[C@H](N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCCC2=O)nc1C)C(F)(F)F

InChI Key: InChIKey=LLUGOCWVLNJQNI-AWEZNQCLSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489237   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM489237 (5-(4-Methyl-2-{[6-(2-oxopyrrolidin-1-yl)pyridin-2-...) Show SMILES C[C@H](N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCCC2=O)nc1C)C(F)(F)F |r| Show InChI InChI=1S/C25H24F3N5O4S2/c1-13-22(38-24(29-13)31-18-6-4-7-19(30-18)32-9-5-8-20(32)34)15-10-16-12-33(14(2)25(26,27)28)23(35)21(16)17(11-15)39(3,36)37/h4,6-7,10-11,14H,5,8-9,12H2,1-3H3,(H,29,30,31)/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM489237 (5-(4-Methyl-2-{[6-(2-oxopyrrolidin-1-yl)pyridin-2-...) Show SMILES C[C@H](N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCCC2=O)nc1C)C(F)(F)F |r| Show InChI InChI=1S/C25H24F3N5O4S2/c1-13-22(38-24(29-13)31-18-6-4-7-19(30-18)32-9-5-8-20(32)34)15-10-16-12-33(14(2)25(26,27)28)23(35)21(16)17(11-15)39(3,36)37/h4,6-7,10-11,14H,5,8-9,12H2,1-3H3,(H,29,30,31)/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	575	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM489237 (5-(4-Methyl-2-{[6-(2-oxopyrrolidin-1-yl)pyridin-2-...) Show SMILES C[C@H](N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCCC2=O)nc1C)C(F)(F)F |r| Show InChI InChI=1S/C25H24F3N5O4S2/c1-13-22(38-24(29-13)31-18-6-4-7-19(30-18)32-9-5-8-20(32)34)15-10-16-12-33(14(2)25(26,27)28)23(35)21(16)17(11-15)39(3,36)37/h4,6-7,10-11,14H,5,8-9,12H2,1-3H3,(H,29,30,31)/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [144-1102] (Homo sapiens (Human))	BDBM489237 (5-(4-Methyl-2-{[6-(2-oxopyrrolidin-1-yl)pyridin-2-...) Show SMILES C[C@H](N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCCC2=O)nc1C)C(F)(F)F |r| Show InChI InChI=1S/C25H24F3N5O4S2/c1-13-22(38-24(29-13)31-18-6-4-7-19(30-18)32-9-5-8-20(32)34)15-10-16-12-33(14(2)25(26,27)28)23(35)21(16)17(11-15)39(3,36)37/h4,6-7,10-11,14H,5,8-9,12H2,1-3H3,(H,29,30,31)/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair