null

SMILES: C[C@H](N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCNC2=O)nc1C)C(F)(F)F

InChI Key: InChIKey=BMEVMMHSZQHXGB-ZDUSSCGKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489238   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM489238 (5-(4-Methyl-2-{[6-(2-oxoimidazolidin-1-yl)pyridin-...) Show SMILES C[C@H](N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCNC2=O)nc1C)C(F)(F)F |r| Show InChI InChI=1S/C24H23F3N6O4S2/c1-12-20(38-22(29-12)31-17-5-4-6-18(30-17)32-8-7-28-23(32)35)14-9-15-11-33(13(2)24(25,26)27)21(34)19(15)16(10-14)39(3,36)37/h4-6,9-10,13H,7-8,11H2,1-3H3,(H,28,35)(H,29,30,31)/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM489238 (5-(4-Methyl-2-{[6-(2-oxoimidazolidin-1-yl)pyridin-...) Show SMILES C[C@H](N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCNC2=O)nc1C)C(F)(F)F |r| Show InChI InChI=1S/C24H23F3N6O4S2/c1-12-20(38-22(29-12)31-17-5-4-6-18(30-17)32-8-7-28-23(32)35)14-9-15-11-33(13(2)24(25,26)27)21(34)19(15)16(10-14)39(3,36)37/h4-6,9-10,13H,7-8,11H2,1-3H3,(H,28,35)(H,29,30,31)/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	291	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM489238 (5-(4-Methyl-2-{[6-(2-oxoimidazolidin-1-yl)pyridin-...) Show SMILES C[C@H](N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCNC2=O)nc1C)C(F)(F)F |r| Show InChI InChI=1S/C24H23F3N6O4S2/c1-12-20(38-22(29-12)31-17-5-4-6-18(30-17)32-8-7-28-23(32)35)14-9-15-11-33(13(2)24(25,26)27)21(34)19(15)16(10-14)39(3,36)37/h4-6,9-10,13H,7-8,11H2,1-3H3,(H,28,35)(H,29,30,31)/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [144-1102] (Homo sapiens (Human))	BDBM489238 (5-(4-Methyl-2-{[6-(2-oxoimidazolidin-1-yl)pyridin-...) Show SMILES C[C@H](N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCNC2=O)nc1C)C(F)(F)F |r| Show InChI InChI=1S/C24H23F3N6O4S2/c1-12-20(38-22(29-12)31-17-5-4-6-18(30-17)32-8-7-28-23(32)35)14-9-15-11-33(13(2)24(25,26)27)21(34)19(15)16(10-14)39(3,36)37/h4-6,9-10,13H,7-8,11H2,1-3H3,(H,28,35)(H,29,30,31)/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair