null

SMILES: CCOCC(=O)N(C)c1cccc(Nc2nc(C)c(s2)-c2cc3CN([C@@H](C)C4CC4)C(=O)c3c(c2)S(=O)(=O)NC)n1

InChI Key: InChIKey=FLUPYHUXCIWKAE-KRWDZBQOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489244   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM489244 (N-{6-[(5-{2-[(1S)-1-Cyclopropylethyl]-7-(methylsul...) Show SMILES CCOCC(=O)N(C)c1cccc(Nc2nc(C)c(s2)-c2cc3CN([C@@H](C)C4CC4)C(=O)c3c(c2)S(=O)(=O)NC)n1 |r| Show InChI InChI=1S/C28H34N6O5S2/c1-6-39-15-24(35)33(5)23-9-7-8-22(31-23)32-28-30-16(2)26(40-28)19-12-20-14-34(17(3)18-10-11-18)27(36)25(20)21(13-19)41(37,38)29-4/h7-9,12-13,17-18,29H,6,10-11,14-15H2,1-5H3,(H,30,31,32)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM489244 (N-{6-[(5-{2-[(1S)-1-Cyclopropylethyl]-7-(methylsul...) Show SMILES CCOCC(=O)N(C)c1cccc(Nc2nc(C)c(s2)-c2cc3CN([C@@H](C)C4CC4)C(=O)c3c(c2)S(=O)(=O)NC)n1 |r| Show InChI InChI=1S/C28H34N6O5S2/c1-6-39-15-24(35)33(5)23-9-7-8-22(31-23)32-28-30-16(2)26(40-28)19-12-20-14-34(17(3)18-10-11-18)27(36)25(20)21(13-19)41(37,38)29-4/h7-9,12-13,17-18,29H,6,10-11,14-15H2,1-5H3,(H,30,31,32)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	677	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM489244 (N-{6-[(5-{2-[(1S)-1-Cyclopropylethyl]-7-(methylsul...) Show SMILES CCOCC(=O)N(C)c1cccc(Nc2nc(C)c(s2)-c2cc3CN([C@@H](C)C4CC4)C(=O)c3c(c2)S(=O)(=O)NC)n1 |r| Show InChI InChI=1S/C28H34N6O5S2/c1-6-39-15-24(35)33(5)23-9-7-8-22(31-23)32-28-30-16(2)26(40-28)19-12-20-14-34(17(3)18-10-11-18)27(36)25(20)21(13-19)41(37,38)29-4/h7-9,12-13,17-18,29H,6,10-11,14-15H2,1-5H3,(H,30,31,32)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [144-1102] (Homo sapiens (Human))	BDBM489244 (N-{6-[(5-{2-[(1S)-1-Cyclopropylethyl]-7-(methylsul...) Show SMILES CCOCC(=O)N(C)c1cccc(Nc2nc(C)c(s2)-c2cc3CN([C@@H](C)C4CC4)C(=O)c3c(c2)S(=O)(=O)NC)n1 |r| Show InChI InChI=1S/C28H34N6O5S2/c1-6-39-15-24(35)33(5)23-9-7-8-22(31-23)32-28-30-16(2)26(40-28)19-12-20-14-34(17(3)18-10-11-18)27(36)25(20)21(13-19)41(37,38)29-4/h7-9,12-13,17-18,29H,6,10-11,14-15H2,1-5H3,(H,30,31,32)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair