null

SMILES: CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCCOC2=O)nc1C

InChI Key: InChIKey=RVJDAOWTYAVAHK-INIZCTEOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489248   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM489248 (2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...) Show SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCCOC2=O)nc1C |r| Show InChI InChI=1S/C27H30N6O5S2/c1-15-24(39-26(29-15)31-21-6-4-7-22(30-21)32-10-5-11-38-27(32)35)18-12-19-14-33(16(2)17-8-9-17)25(34)23(19)20(13-18)40(36,37)28-3/h4,6-7,12-13,16-17,28H,5,8-11,14H2,1-3H3,(H,29,30,31)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM489248 (2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...) Show SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCCOC2=O)nc1C |r| Show InChI InChI=1S/C27H30N6O5S2/c1-15-24(39-26(29-15)31-21-6-4-7-22(30-21)32-10-5-11-38-27(32)35)18-12-19-14-33(16(2)17-8-9-17)25(34)23(19)20(13-18)40(36,37)28-3/h4,6-7,12-13,16-17,28H,5,8-11,14H2,1-3H3,(H,29,30,31)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	103	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM489248 (2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...) Show SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCCOC2=O)nc1C |r| Show InChI InChI=1S/C27H30N6O5S2/c1-15-24(39-26(29-15)31-21-6-4-7-22(30-21)32-10-5-11-38-27(32)35)18-12-19-14-33(16(2)17-8-9-17)25(34)23(19)20(13-18)40(36,37)28-3/h4,6-7,12-13,16-17,28H,5,8-11,14H2,1-3H3,(H,29,30,31)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [144-1102] (Homo sapiens (Human))	BDBM489248 (2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...) Show SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCCOC2=O)nc1C |r| Show InChI InChI=1S/C27H30N6O5S2/c1-15-24(39-26(29-15)31-21-6-4-7-22(30-21)32-10-5-11-38-27(32)35)18-12-19-14-33(16(2)17-8-9-17)25(34)23(19)20(13-18)40(36,37)28-3/h4,6-7,12-13,16-17,28H,5,8-11,14H2,1-3H3,(H,29,30,31)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair