null

SMILES: CCNS(=O)(=O)c1cc(cc2CN([C@@H](C)C(F)(F)F)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCOCC2=O)nc1C

InChI Key: InChIKey=XDWSNPNGAFALHJ-HNNXBMFYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489254   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM489254 (N-Ethyl-6-(4-methyl-2-{[6-(3-oxomorpholin-4-yl)pyr...) Show SMILES CCNS(=O)(=O)c1cc(cc2CN([C@@H](C)C(F)(F)F)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCOCC2=O)nc1C |r| Show InChI InChI=1S/C26H27F3N6O5S2/c1-4-30-42(38,39)18-11-16(10-17-12-35(24(37)22(17)18)15(3)26(27,28)29)23-14(2)31-25(41-23)33-19-6-5-7-20(32-19)34-8-9-40-13-21(34)36/h5-7,10-11,15,30H,4,8-9,12-13H2,1-3H3,(H,31,32,33)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM489254 (N-Ethyl-6-(4-methyl-2-{[6-(3-oxomorpholin-4-yl)pyr...) Show SMILES CCNS(=O)(=O)c1cc(cc2CN([C@@H](C)C(F)(F)F)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCOCC2=O)nc1C |r| Show InChI InChI=1S/C26H27F3N6O5S2/c1-4-30-42(38,39)18-11-16(10-17-12-35(24(37)22(17)18)15(3)26(27,28)29)23-14(2)31-25(41-23)33-19-6-5-7-20(32-19)34-8-9-40-13-21(34)36/h5-7,10-11,15,30H,4,8-9,12-13H2,1-3H3,(H,31,32,33)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	178	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM489254 (N-Ethyl-6-(4-methyl-2-{[6-(3-oxomorpholin-4-yl)pyr...) Show SMILES CCNS(=O)(=O)c1cc(cc2CN([C@@H](C)C(F)(F)F)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCOCC2=O)nc1C |r| Show InChI InChI=1S/C26H27F3N6O5S2/c1-4-30-42(38,39)18-11-16(10-17-12-35(24(37)22(17)18)15(3)26(27,28)29)23-14(2)31-25(41-23)33-19-6-5-7-20(32-19)34-8-9-40-13-21(34)36/h5-7,10-11,15,30H,4,8-9,12-13H2,1-3H3,(H,31,32,33)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [144-1102] (Homo sapiens (Human))	BDBM489254 (N-Ethyl-6-(4-methyl-2-{[6-(3-oxomorpholin-4-yl)pyr...) Show SMILES CCNS(=O)(=O)c1cc(cc2CN([C@@H](C)C(F)(F)F)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCOCC2=O)nc1C |r| Show InChI InChI=1S/C26H27F3N6O5S2/c1-4-30-42(38,39)18-11-16(10-17-12-35(24(37)22(17)18)15(3)26(27,28)29)23-14(2)31-25(41-23)33-19-6-5-7-20(32-19)34-8-9-40-13-21(34)36/h5-7,10-11,15,30H,4,8-9,12-13H2,1-3H3,(H,31,32,33)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair