null

SMILES: C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(=O)(=O)NC1COC1)-c1sc(Nc2cccc(n2)N2CCCOC2=O)nc1C

InChI Key: InChIKey=UUXKXNLWIZYSGT-KRWDZBQOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489262   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM489262 (2-[(1S)-1-Cyclopropylethyl]-6-(4-methyl-2-{[6-(2-o...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(=O)(=O)NC1COC1)-c1sc(Nc2cccc(n2)N2CCCOC2=O)nc1C |r| Show InChI InChI=1S/C29H32N6O6S2/c1-16-26(42-28(30-16)32-23-5-3-6-24(31-23)34-9-4-10-41-29(34)37)19-11-20-13-35(17(2)18-7-8-18)27(36)25(20)22(12-19)43(38,39)33-21-14-40-15-21/h3,5-6,11-12,17-18,21,33H,4,7-10,13-15H2,1-2H3,(H,30,31,32)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM489262 (2-[(1S)-1-Cyclopropylethyl]-6-(4-methyl-2-{[6-(2-o...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(=O)(=O)NC1COC1)-c1sc(Nc2cccc(n2)N2CCCOC2=O)nc1C |r| Show InChI InChI=1S/C29H32N6O6S2/c1-16-26(42-28(30-16)32-23-5-3-6-24(31-23)34-9-4-10-41-29(34)37)19-11-20-13-35(17(2)18-7-8-18)27(36)25(20)22(12-19)43(38,39)33-21-14-40-15-21/h3,5-6,11-12,17-18,21,33H,4,7-10,13-15H2,1-2H3,(H,30,31,32)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	484	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM489262 (2-[(1S)-1-Cyclopropylethyl]-6-(4-methyl-2-{[6-(2-o...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(=O)(=O)NC1COC1)-c1sc(Nc2cccc(n2)N2CCCOC2=O)nc1C |r| Show InChI InChI=1S/C29H32N6O6S2/c1-16-26(42-28(30-16)32-23-5-3-6-24(31-23)34-9-4-10-41-29(34)37)19-11-20-13-35(17(2)18-7-8-18)27(36)25(20)22(12-19)43(38,39)33-21-14-40-15-21/h3,5-6,11-12,17-18,21,33H,4,7-10,13-15H2,1-2H3,(H,30,31,32)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [144-1102] (Homo sapiens (Human))	BDBM489262 (2-[(1S)-1-Cyclopropylethyl]-6-(4-methyl-2-{[6-(2-o...) Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(=O)(=O)NC1COC1)-c1sc(Nc2cccc(n2)N2CCCOC2=O)nc1C |r| Show InChI InChI=1S/C29H32N6O6S2/c1-16-26(42-28(30-16)32-23-5-3-6-24(31-23)34-9-4-10-41-29(34)37)19-11-20-13-35(17(2)18-7-8-18)27(36)25(20)22(12-19)43(38,39)33-21-14-40-15-21/h3,5-6,11-12,17-18,21,33H,4,7-10,13-15H2,1-2H3,(H,30,31,32)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair