null

SMILES: CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CC[C@@H](O)C2=O)nc1C

InChI Key: InChIKey=UCWFGTHMIDAVDE-HNAYVOBHSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489281   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM489281 (2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(3R)-3-hydro...) Show SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CC[C@@H](O)C2=O)nc1C |r| Show InChI InChI=1S/C27H30N6O5S2/c1-14-24(39-27(29-14)31-21-5-4-6-22(30-21)32-10-9-19(34)25(32)35)17-11-18-13-33(15(2)16-7-8-16)26(36)23(18)20(12-17)40(37,38)28-3/h4-6,11-12,15-16,19,28,34H,7-10,13H2,1-3H3,(H,29,30,31)/t15-,19+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM489281 (2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(3R)-3-hydro...) Show SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CC[C@@H](O)C2=O)nc1C |r| Show InChI InChI=1S/C27H30N6O5S2/c1-14-24(39-27(29-14)31-21-5-4-6-22(30-21)32-10-9-19(34)25(32)35)17-11-18-13-33(15(2)16-7-8-16)26(36)23(18)20(12-17)40(37,38)28-3/h4-6,11-12,15-16,19,28,34H,7-10,13H2,1-3H3,(H,29,30,31)/t15-,19+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	325	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM489281 (2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(3R)-3-hydro...) Show SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CC[C@@H](O)C2=O)nc1C |r| Show InChI InChI=1S/C27H30N6O5S2/c1-14-24(39-27(29-14)31-21-5-4-6-22(30-21)32-10-9-19(34)25(32)35)17-11-18-13-33(15(2)16-7-8-16)26(36)23(18)20(12-17)40(37,38)28-3/h4-6,11-12,15-16,19,28,34H,7-10,13H2,1-3H3,(H,29,30,31)/t15-,19+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [144-1102] (Homo sapiens (Human))	BDBM489281 (2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(3R)-3-hydro...) Show SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CC[C@@H](O)C2=O)nc1C |r| Show InChI InChI=1S/C27H30N6O5S2/c1-14-24(39-27(29-14)31-21-5-4-6-22(30-21)32-10-9-19(34)25(32)35)17-11-18-13-33(15(2)16-7-8-16)26(36)23(18)20(12-17)40(37,38)28-3/h4-6,11-12,15-16,19,28,34H,7-10,13H2,1-3H3,(H,29,30,31)/t15-,19+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021)
					More data for this Ligand-Target Pair