null

SMILES: CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1c(C)cccc1F)-n1nc2CCCCn2c1=O

InChI Key: InChIKey=QBZVRQSTSPLRNU-INIZCTEOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 490360   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490360 (5-fluoro-N-(2-fluoro-6-methylphenyl)-4-(3-oxo-5,6,...) Show SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1c(C)cccc1F)-n1nc2CCCCn2c1=O |r| Show InChI InChI=1S/C25H28F2N4O3/c1-4-8-16(3)34-21-14-20(31-25(33)30-12-6-5-11-22(30)29-31)19(27)13-17(21)24(32)28-23-15(2)9-7-10-18(23)26/h7,9-10,13-14,16H,4-6,8,11-12H2,1-3H3,(H,28,32)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021)
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490360 (5-fluoro-N-(2-fluoro-6-methylphenyl)-4-(3-oxo-5,6,...) Show SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1c(C)cccc1F)-n1nc2CCCCn2c1=O |r| Show InChI InChI=1S/C25H28F2N4O3/c1-4-8-16(3)34-21-14-20(31-25(33)30-12-6-5-11-22(30)29-31)19(27)13-17(21)24(32)28-23-15(2)9-7-10-18(23)26/h7,9-10,13-14,16H,4-6,8,11-12H2,1-3H3,(H,28,32)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	92.5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021)
					More data for this Ligand-Target Pair