null

SMILES: C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(C)cccc1F)-n1nc2CCCCn2c1=O)c1ccccc1

InChI Key: InChIKey=IVIPHRSTYHYZFE-SFHVURJKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 490595   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490595 (5-fluoro-N-(2-fluoro-6-methylphenyl)-4-(3-oxo-5,6,...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(C)cccc1F)-n1nc2CCCCn2c1=O)c1ccccc1 |r| Show InChI InChI=1S/C28H26F2N4O3/c1-17-9-8-12-21(29)26(17)31-27(35)20-15-22(30)23(34-28(36)33-14-7-6-13-25(33)32-34)16-24(20)37-18(2)19-10-4-3-5-11-19/h3-5,8-12,15-16,18H,6-7,13-14H2,1-2H3,(H,31,35)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021)
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490595 (5-fluoro-N-(2-fluoro-6-methylphenyl)-4-(3-oxo-5,6,...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(C)cccc1F)-n1nc2CCCCn2c1=O)c1ccccc1 |r| Show InChI InChI=1S/C28H26F2N4O3/c1-17-9-8-12-21(29)26(17)31-27(35)20-15-22(30)23(34-28(36)33-14-7-6-13-25(33)32-34)16-24(20)37-18(2)19-10-4-3-5-11-19/h3-5,8-12,15-16,18H,6-7,13-14H2,1-2H3,(H,31,35)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.7	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021)
					More data for this Ligand-Target Pair