BDBM494440 (R)-N-(6- (cyclopropylmethoxy)-2- (2-fluoro-3-hydroxy-3- methylbutyl)-1- oxoisoindolin-5- yl)pyrazolo[1,5- a]pyrimidine-3- carboxamide::US10988478, Example 496

SMILES: CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(OCC3CC3)cc2C1=O

InChI Key: InChIKey=JZGBDVBGAVSSCF-HXUWFJFHSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 494440   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM494440 ((R)-N-(6- (cyclopropylmethoxy)-2- (2-fluoro-3-hydr...) Show SMILES CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(OCC3CC3)cc2C1=O |r| Show InChI InChI=1S/C24H26FN5O4/c1-24(2,33)20(25)12-29-11-15-8-18(19(9-16(15)23(29)32)34-13-14-4-5-14)28-22(31)17-10-27-30-7-3-6-26-21(17)30/h3,6-10,14,20,33H,4-5,11-13H2,1-2H3,(H,28,31)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.830	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Kinase activities were assayed using the Transcreener-Fluorecescence polarization platform (BelBrook Labs, Madison, Wis., USA) that measures amounts ...				US Patent US10988478 (2021)
					More data for this Ligand-Target Pair