BDBM494453 N-(6-(4-((1H-imidazol-4- yl)-2,2-dimethyl-2,3- yl)methyl)piperazin-1- dihydrobenzofuran-5- yl)pyrazolo[1,5- a]pyrimidine-3- carboxamide::US10988478, Example 509

SMILES: CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(cc2O1)N1CCN(Cc2c[nH]cn2)CC1

InChI Key: InChIKey=IQUVSFJLVSGECK-UHFFFAOYSA-N

Data: 1 KI

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 494453   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM494453 (N-(6-(4-((1H-imidazol-4- yl)-2,2-dimethyl-2,3- yl)...) Show SMILES CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(cc2O1)N1CCN(Cc2c[nH]cn2)CC1 Show InChI InChI=1S/C25H28N8O2/c1-25(2)12-17-10-20(30-24(34)19-14-29-33-5-3-4-27-23(19)33)21(11-22(17)35-25)32-8-6-31(7-9-32)15-18-13-26-16-28-18/h3-5,10-11,13-14,16H,6-9,12,15H2,1-2H3,(H,26,28)(H,30,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Kinase activities were assayed using the Transcreener-Fluorecescence polarization platform (BelBrook Labs, Madison, Wis., USA) that measures amounts ...				US Patent US10988478 (2021)
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