BDBM494824 N-(4-fluorobicyclo[4.2.0]octa- 1,3,5-trien-7-yl)-N'-hydroxy-4-{[- (methylsulfonyl)ethyl]amino}- 1,2,5-oxadiazole-3- carboximidamide::US10988487, Example 220

SMILES: CS(=O)(=O)CCNc1nonc1\C(NC1Cc2ccc(F)cc12)=N\O

InChI Key: InChIKey=KYXCRISQJRNWKM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 494824   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM494824 (N-(4-fluorobicyclo[4.2.0]octa- 1,3,5-trien-7-yl)-N...) Show SMILES CS(=O)(=O)CCNc1nonc1\C(NC1Cc2ccc(F)cc12)=N\O Show InChI InChI=1S/C14H16FN5O4S/c1-25(22,23)5-4-16-13-12(19-24-20-13)14(18-21)17-11-6-8-2-3-9(15)7-10(8)11/h2-3,7,11,21H,4-6H2,1H3,(H,16,20)(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...				US Patent US10988487 (2021)
					More data for this Ligand-Target Pair