BDBM494833 N-[(7S)-4- fluorobicyclo[4.2.0]octa-1,3,5- trien-7-yl]-N'-hydroxy-4-[(1- sulfamoylazetidin-3- yl)sulfanyl]-1,2,5-oxadiazole- 3-carboximidamide::US10988487, Example 229

SMILES: NS(=O)(=O)N1CC(C1)Sc1nonc1\C(N[C@H]1Cc2ccc(F)cc12)=N\O

InChI Key: InChIKey=QIIOASBTTNUAGL-NSHDSACASA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 494833   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM494833 (N-[(7S)-4- fluorobicyclo[4.2.0]octa-1,3,5- trien-7...) Show SMILES NS(=O)(=O)N1CC(C1)Sc1nonc1\C(N[C@H]1Cc2ccc(F)cc12)=N\O |r| Show InChI InChI=1S/C14H15FN6O4S2/c15-8-2-1-7-3-11(10(7)4-8)17-13(18-22)12-14(20-25-19-12)26-9-5-21(6-9)27(16,23)24/h1-2,4,9,11,22H,3,5-6H2,(H,17,18)(H2,16,23,24)/t11-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50.3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...				US Patent US10988487 (2021)
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