BDBM494887 US10988463, Example 16::[(1R,5S,6R)-3-{5-chloro-2-[(2S,3R)-3-hydroxy-2-methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl}-3-azabicyclo[3.1.0]hex-6-yl]acetic acid

SMILES: C[C@H]1[C@H](O)CN1c1nc(N2CC3C(CC(O)=O)C3C2)c(Cl)c(n1)C(F)(F)F

InChI Key: InChIKey=FYIIVGGOOVQJJT-HRLXQSQDSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 494887   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ketohexokinase (KHK) Isoform C (Homo sapiens (Human))	BDBM494887 (US10988463, Example 16 | [(1R,5S,6R)-3-{5-chloro-2...) Show SMILES C[C@H]1[C@H](O)CN1c1nc(N2CC3C(CC(O)=O)C3C2)c(Cl)c(n1)C(F)(F)F Show InChI InChI=1S/C16H18ClF3N4O3/c1-6-10(25)5-24(6)15-21-13(16(18,19)20)12(17)14(22-15)23-3-8-7(2-11(26)27)9(8)4-23/h6-10,25H,2-5H2,1H3,(H,26,27)/t6-,7?,8?,9?,10+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Assay A, a 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepa...				US Patent US10988463 (2021)
					More data for this Ligand-Target Pair