BDBM494936 2-(2,6-dioxopiperidin-3-yl)-5-(4-(2-(1-(4-((1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-4-methoxypiperidin-4-yl)ethyl)piperazin-1-yl)isoindoline-1,3-dione::US10994015, Example 78

SMILES: COC1(CCN2CCN(CC2)c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CCN(CC1)c1nccc(Nc2cc3n(C(C)C)c(C)nc3cn2)n1

InChI Key: InChIKey=FOVZAELMJWNOAX-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 494936   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM494936 (2-(2,6-dioxopiperidin-3-yl)-5-(4-(2-(1-(4-((1-isop...) Show SMILES COC1(CCN2CCN(CC2)c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CCN(CC1)c1nccc(Nc2cc3n(C(C)C)c(C)nc3cn2)n1 Show InChI InChI=1S/C39H47N11O5/c1-24(2)49-25(3)42-29-23-41-33(22-31(29)49)43-32-9-13-40-38(44-32)48-15-11-39(55-4,12-16-48)10-14-46-17-19-47(20-18-46)26-5-6-27-28(21-26)37(54)50(36(27)53)30-7-8-34(51)45-35(30)52/h5-6,9,13,21-24,30H,7-8,10-12,14-20H2,1-4H3,(H,45,51,52)(H,40,41,43,44)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent					Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...				US Patent US10994015 (2021)
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM494936 (2-(2,6-dioxopiperidin-3-yl)-5-(4-(2-(1-(4-((1-isop...) Show SMILES COC1(CCN2CCN(CC2)c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CCN(CC1)c1nccc(Nc2cc3n(C(C)C)c(C)nc3cn2)n1 Show InChI InChI=1S/C39H47N11O5/c1-24(2)49-25(3)42-29-23-41-33(22-31(29)49)43-32-9-13-40-38(44-32)48-15-11-39(55-4,12-16-48)10-14-46-17-19-47(20-18-46)26-5-6-27-28(21-26)37(54)50(36(27)53)30-7-8-34(51)45-35(30)52/h5-6,9,13,21-24,30H,7-8,10-12,14-20H2,1-4H3,(H,45,51,52)(H,40,41,43,44)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent					Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...				US Patent US10994015 (2021)
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3 (Homo sapiens (Human))	BDBM494936 (2-(2,6-dioxopiperidin-3-yl)-5-(4-(2-(1-(4-((1-isop...) Show SMILES COC1(CCN2CCN(CC2)c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CCN(CC1)c1nccc(Nc2cc3n(C(C)C)c(C)nc3cn2)n1 Show InChI InChI=1S/C39H47N11O5/c1-24(2)49-25(3)42-29-23-41-33(22-31(29)49)43-32-9-13-40-38(44-32)48-15-11-39(55-4,12-16-48)10-14-46-17-19-47(20-18-46)26-5-6-27-28(21-26)37(54)50(36(27)53)30-7-8-34(51)45-35(30)52/h5-6,9,13,21-24,30H,7-8,10-12,14-20H2,1-4H3,(H,45,51,52)(H,40,41,43,44)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent					Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...				US Patent US10994015 (2021)
					More data for this Ligand-Target Pair
EGFR (L858R, T790M, C797S) (Homo sapiens (Human))	BDBM494936 (2-(2,6-dioxopiperidin-3-yl)-5-(4-(2-(1-(4-((1-isop...) Show SMILES COC1(CCN2CCN(CC2)c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CCN(CC1)c1nccc(Nc2cc3n(C(C)C)c(C)nc3cn2)n1 Show InChI InChI=1S/C39H47N11O5/c1-24(2)49-25(3)42-29-23-41-33(22-31(29)49)43-32-9-13-40-38(44-32)48-15-11-39(55-4,12-16-48)10-14-46-17-19-47(20-18-46)26-5-6-27-28(21-26)37(54)50(36(27)53)30-7-8-34(51)45-35(30)52/h5-6,9,13,21-24,30H,7-8,10-12,14-20H2,1-4H3,(H,45,51,52)(H,40,41,43,44)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent					Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...				US Patent US10994015 (2021)
					More data for this Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M) (Homo sapiens (Human))	BDBM494936 (2-(2,6-dioxopiperidin-3-yl)-5-(4-(2-(1-(4-((1-isop...) Show SMILES COC1(CCN2CCN(CC2)c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CCN(CC1)c1nccc(Nc2cc3n(C(C)C)c(C)nc3cn2)n1 Show InChI InChI=1S/C39H47N11O5/c1-24(2)49-25(3)42-29-23-41-33(22-31(29)49)43-32-9-13-40-38(44-32)48-15-11-39(55-4,12-16-48)10-14-46-17-19-47(20-18-46)26-5-6-27-28(21-26)37(54)50(36(27)53)30-7-8-34(51)45-35(30)52/h5-6,9,13,21-24,30H,7-8,10-12,14-20H2,1-4H3,(H,45,51,52)(H,40,41,43,44)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent					Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...				US Patent US10994015 (2021)
					More data for this Ligand-Target Pair