BDBM50005043 5,7-Dichloro-4-(3-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-1,2,3,4-tetrahydro-quinoline-2-carboxylic acid::CHEMBL58746

SMILES: OC(=O)[C@H]1C[C@H](N2Cc3ccccc3CC2=O)c2c(Cl)cc(Cl)cc2N1

InChI Key: InChIKey=JTBZTAAONTZFHD-CVEARBPZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50005043   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50005043 (5,7-Dichloro-4-(3-oxo-3,4-dihydro-1H-isoquinolin-2...) Show SMILES OC(=O)[C@H]1C[C@H](N2Cc3ccccc3CC2=O)c2c(Cl)cc(Cl)cc2N1 Show InChI InChI=1S/C19H16Cl2N2O3/c20-12-6-13(21)18-14(7-12)22-15(19(25)26)8-16(18)23-9-11-4-2-1-3-10(11)5-17(23)24/h1-4,6-7,15-16,22H,5,8-9H2,(H,25,26)/t15-,16+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.				J Med Chem 35: 1954-68 (1992) BindingDB Entry DOI: 10.7270/Q2T72GCZ
					More data for this Ligand-Target Pair