BDBM50006472 CHEMBL69183::[6-Oxo-1-(5-trifluoromethyl-benzothiazol-2-ylmethyl)-1,6-dihydro-pyridazin-3-yl]-acetic acid

SMILES: OC(=O)Cc1ccc(=O)n(Cc2nc3cc(ccc3s2)C(F)(F)F)n1

InChI Key: InChIKey=HJYHQUAVPCYWBM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50006472   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldose reductase (AR) (Homo sapiens (Human))	BDBM50006472 (CHEMBL69183 | [6-Oxo-1-(5-trifluoromethyl-benzothi...) Show SMILES OC(=O)Cc1ccc(=O)n(Cc2nc3cc(ccc3s2)C(F)(F)F)n1 Show InChI InChI=1S/C15H10F3N3O3S/c16-15(17,18)8-1-3-11-10(5-8)19-12(25-11)7-21-13(22)4-2-9(20-21)6-14(23)24/h1-5H,6-7H2,(H,23,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibitory activity against aldose reductase isolated from human placenta				J Med Chem 35: 2155-62 (1992) BindingDB Entry DOI: 10.7270/Q2KK99RR
					More data for this Ligand-Target Pair