BDBM50006479 CHEMBL69371::[7-(4-Bromo-2-fluoro-benzyl)-8-oxo-7,8-dihydro-pyrido[2,3-d]pyridazin-5-yl]-acetic acid

SMILES: OC(=O)Cc1nn(Cc2ccc(Br)cc2F)c(=O)c2ncccc12

InChI Key: InChIKey=XFFKMUMASJSILS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50006479   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldose reductase (AR) (Homo sapiens (Human))	BDBM50006479 (CHEMBL69371 | [7-(4-Bromo-2-fluoro-benzyl)-8-oxo-7...) Show SMILES OC(=O)Cc1nn(Cc2ccc(Br)cc2F)c(=O)c2ncccc12 Show InChI InChI=1S/C16H11BrFN3O3/c17-10-4-3-9(12(18)6-10)8-21-16(24)15-11(2-1-5-19-15)13(20-21)7-14(22)23/h1-6H,7-8H2,(H,22,23)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	760	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibitory activity against aldose reductase isolated from human placenta				J Med Chem 35: 2155-62 (1992) BindingDB Entry DOI: 10.7270/Q2KK99RR
					More data for this Ligand-Target Pair