BDBM50006519 (6-Chloro-7-fluoro-4-hydroxy-2-methyl-chroman-4-yl)-acetic acid::CHEMBL307121

SMILES: C[C@@H]1C[C@@](O)(CC(O)=O)c2cc(Cl)c(F)cc2O1

InChI Key: InChIKey=ZLYVESBCLMPTQI-SREIQFSDSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50006519   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldose reductase (AR) (Homo sapiens (Human))	BDBM50006519 ((6-Chloro-7-fluoro-4-hydroxy-2-methyl-chroman-4-yl...) Show SMILES C[C@@H]1C[C@@](O)(CC(O)=O)c2cc(Cl)c(F)cc2O1 Show InChI InChI=1S/C12H12ClFO4/c1-6-4-12(17,5-11(15)16)7-2-8(13)9(14)3-10(7)18-6/h2-3,6,17H,4-5H2,1H3,(H,15,16)/t6-,12-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Compound was tested in vitro for its inhibitory activity against human placental aldose reductase				J Med Chem 35: 2169-77 (1992) BindingDB Entry DOI: 10.7270/Q2833SN9
					More data for this Ligand-Target Pair
Aldose reductase (Homo sapiens (Human))	BDBM50006519 ((6-Chloro-7-fluoro-4-hydroxy-2-methyl-chroman-4-yl...) Show SMILES C[C@@H]1C[C@@](O)(CC(O)=O)c2cc(Cl)c(F)cc2O1 Show InChI InChI=1S/C12H12ClFO4/c1-6-4-12(17,5-11(15)16)7-2-8(13)9(14)3-10(7)18-6/h2-3,6,17H,4-5H2,1H3,(H,15,16)/t6-,12-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibitory activity against human placental aldose reductase				J Med Chem 35: 2169-77 (1992) BindingDB Entry DOI: 10.7270/Q2833SN9
					More data for this Ligand-Target Pair