BDBM50007042 2-{Methoxy-[3-(naphthalen-2-ylmethoxy)-phenyl]-methyl}-thiazole::CHEMBL304320

SMILES: COC(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1

InChI Key: InChIKey=XUMOXZBAIWUITO-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50007042   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50007042 (2-{Methoxy-[3-(naphthalen-2-ylmethoxy)-phenyl]-met...) Show SMILES COC(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1 Show InChI InChI=1S/C22H19NO2S/c1-24-21(22-23-11-12-26-22)19-7-4-8-20(14-19)25-15-16-9-10-17-5-2-3-6-18(17)13-16/h2-14,21H,15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Compound was tested for the inhibition of 5-lipoxygenase (5-Lpo) in rat whole blood.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50007042 (2-{Methoxy-[3-(naphthalen-2-ylmethoxy)-phenyl]-met...) Show SMILES COC(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1 Show InChI InChI=1S/C22H19NO2S/c1-24-21(22-23-11-12-26-22)19-7-4-8-20(14-19)25-15-16-9-10-17-5-2-3-6-18(17)13-16/h2-14,21H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Compound was tested for the inhibition of 5-lipoxygenase (5-Lpo) in guinea pig.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Mus musculus)	BDBM50007042 (2-{Methoxy-[3-(naphthalen-2-ylmethoxy)-phenyl]-met...) Show SMILES COC(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1 Show InChI InChI=1S/C22H19NO2S/c1-24-21(22-23-11-12-26-22)19-7-4-8-20(14-19)25-15-16-9-10-17-5-2-3-6-18(17)13-16/h2-14,21H,15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in mouse macrophages.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50007042 (2-{Methoxy-[3-(naphthalen-2-ylmethoxy)-phenyl]-met...) Show SMILES COC(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1 Show InChI InChI=1S/C22H19NO2S/c1-24-21(22-23-11-12-26-22)19-7-4-8-20(14-19)25-15-16-9-10-17-5-2-3-6-18(17)13-16/h2-14,21H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human whole blood.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair