BDBM50007100 CHEMBL3237569::US10112928, Compound I-4

SMILES: Cc1cccc(Nc2cc(Oc3cccc(F)c3)nnc2C(N)=O)n1

InChI Key: InChIKey=VZTTZPLGSADLLI-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50007100   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK [360-635] (Homo sapiens (Human))	BDBM50007100 (CHEMBL3237569 | US10112928, Compound I-4) Show SMILES Cc1cccc(Nc2cc(Oc3cccc(F)c3)nnc2C(N)=O)n1 Show InChI InChI=1S/C17H14FN5O2/c1-10-4-2-7-14(20-10)21-13-9-15(22-23-16(13)17(19)24)25-12-6-3-5-11(18)8-12/h2-9H,1H3,(H2,19,24)(H,20,21,22)	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	671	n/a	n/a	n/a	n/a	7.5	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...				US Patent US10112928 (2018) BindingDB Entry DOI: 10.7270/Q2Z03B68
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50007100 (CHEMBL3237569 | US10112928, Compound I-4) Show SMILES Cc1cccc(Nc2cc(Oc3cccc(F)c3)nnc2C(N)=O)n1 Show InChI InChI=1S/C17H14FN5O2/c1-10-4-2-7-14(20-10)21-13-9-15(22-23-16(13)17(19)24)25-12-6-3-5-11(18)8-12/h2-9H,1H3,(H2,19,24)(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	631	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...				J Med Chem 57: 2683-91 (2014) Article DOI: 10.1021/jm401982j BindingDB Entry DOI: 10.7270/Q2HT2QTR
					More data for this Ligand-Target Pair