BDBM50007154 CHEMBL3237577

SMILES: CC(C)c1nc(Nc2cc(NCCN)nnc2C(N)=O)ccc1C

InChI Key: InChIKey=NUKCYKDQOKEXIH-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50007154   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50007154 (CHEMBL3237577) Show SMILES CC(C)c1nc(Nc2cc(NCCN)nnc2C(N)=O)ccc1C Show InChI InChI=1S/C16H23N7O/c1-9(2)14-10(3)4-5-12(21-14)20-11-8-13(19-7-6-17)22-23-15(11)16(18)24/h4-5,8-9H,6-7,17H2,1-3H3,(H2,18,24)(H2,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...				J Med Chem 57: 2683-91 (2014) Article DOI: 10.1021/jm401982j BindingDB Entry DOI: 10.7270/Q2HT2QTR
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50007154 (CHEMBL3237577) Show SMILES CC(C)c1nc(Nc2cc(NCCN)nnc2C(N)=O)ccc1C Show InChI InChI=1S/C16H23N7O/c1-9(2)14-10(3)4-5-12(21-14)20-11-8-13(19-7-6-17)22-23-15(11)16(18)24/h4-5,8-9H,6-7,17H2,1-3H3,(H2,18,24)(H2,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in CHO cells by patch clamp method				J Med Chem 57: 2683-91 (2014) Article DOI: 10.1021/jm401982j BindingDB Entry DOI: 10.7270/Q2HT2QTR
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50007154 (CHEMBL3237577) Show SMILES CC(C)c1nc(Nc2cc(NCCN)nnc2C(N)=O)ccc1C Show InChI InChI=1S/C16H23N7O/c1-9(2)14-10(3)4-5-12(21-14)20-11-8-13(19-7-6-17)22-23-15(11)16(18)24/h4-5,8-9H,6-7,17H2,1-3H3,(H2,18,24)(H2,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Inhibition of SYK in human whole blood assessed as anti-human IgM-induced CD69 protein expression preincubated for 30 mins followed by anti-human IgM...				J Med Chem 57: 2683-91 (2014) Article DOI: 10.1021/jm401982j BindingDB Entry DOI: 10.7270/Q2HT2QTR
					More data for this Ligand-Target Pair