Found 4 hits for monomerid = 50007211 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50007211
(CHEMBL3237923)Show SMILES CCC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:12.16,3.2,wD:9.10,c:7,(54.02,-13.47,;55.35,-12.68,;55.33,-11.14,;56.65,-10.36,;56.6,-8.82,;57.81,-7.87,;59.29,-8.29,;57.28,-6.42,;55.73,-6.48,;55.32,-7.96,;54.13,-6.98,;52.69,-7.51,;52.42,-9.02,;53.61,-10.01,;55.06,-9.48,;50.98,-9.56,;49.8,-8.57,;49.54,-10.09,;50.72,-11.07,;58.05,-5.09,;57.29,-3.76,;58.07,-2.43,;57.3,-1.09,;59.61,-2.43,;60.37,-3.78,;61.91,-3.78,;59.6,-5.11,;57.98,-11.14,;57.96,-12.69,;59.28,-13.47,;60.63,-12.72,;60.65,-11.18,;59.32,-10.4,;61.95,-13.51,;61.93,-15.05,;63.29,-12.76,;64.62,-13.54,;65.96,-12.79,;67.35,-13.42,;68.4,-12.29,;67.64,-10.95,;66.13,-11.25,)| Show InChI InChI=1S/C31H37Cl2N7O2/c1-5-6-25(19-7-9-20(10-8-19)28(41)34-18-26-36-38-39-37-26)40-29(42)27(21-15-23(32)17-24(33)16-21)35-31(40)13-11-22(12-14-31)30(2,3)4/h7-10,15-17,22,25H,5-6,11-14,18H2,1-4H3,(H,34,41)(H,36,37,38,39)/t22-,25-,31-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this Ligand-Target Pair | |
Glucagon-like peptide 1 receptor (GLP-1)
(Homo sapiens (Human)) | BDBM50007211
(CHEMBL3237923)Show SMILES CCC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:12.16,3.2,wD:9.10,c:7,(54.02,-13.47,;55.35,-12.68,;55.33,-11.14,;56.65,-10.36,;56.6,-8.82,;57.81,-7.87,;59.29,-8.29,;57.28,-6.42,;55.73,-6.48,;55.32,-7.96,;54.13,-6.98,;52.69,-7.51,;52.42,-9.02,;53.61,-10.01,;55.06,-9.48,;50.98,-9.56,;49.8,-8.57,;49.54,-10.09,;50.72,-11.07,;58.05,-5.09,;57.29,-3.76,;58.07,-2.43,;57.3,-1.09,;59.61,-2.43,;60.37,-3.78,;61.91,-3.78,;59.6,-5.11,;57.98,-11.14,;57.96,-12.69,;59.28,-13.47,;60.63,-12.72,;60.65,-11.18,;59.32,-10.4,;61.95,-13.51,;61.93,-15.05,;63.29,-12.76,;64.62,-13.54,;65.96,-12.79,;67.35,-13.42,;68.4,-12.29,;67.64,-10.95,;66.13,-11.25,)| Show InChI InChI=1S/C31H37Cl2N7O2/c1-5-6-25(19-7-9-20(10-8-19)28(41)34-18-26-36-38-39-37-26)40-29(42)27(21-15-23(32)17-24(33)16-21)35-31(40)13-11-22(12-14-31)30(2,3)4/h7-10,15-17,22,25H,5-6,11-14,18H2,1-4H3,(H,34,41)(H,36,37,38,39)/t22-,25-,31-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at human GLP-1R expressed in CHO cells assessed as inhibition of GLP-1-stimulated cAMP production preincubated for 30 mins follow... |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50007211
(CHEMBL3237923)Show SMILES CCC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:12.16,3.2,wD:9.10,c:7,(54.02,-13.47,;55.35,-12.68,;55.33,-11.14,;56.65,-10.36,;56.6,-8.82,;57.81,-7.87,;59.29,-8.29,;57.28,-6.42,;55.73,-6.48,;55.32,-7.96,;54.13,-6.98,;52.69,-7.51,;52.42,-9.02,;53.61,-10.01,;55.06,-9.48,;50.98,-9.56,;49.8,-8.57,;49.54,-10.09,;50.72,-11.07,;58.05,-5.09,;57.29,-3.76,;58.07,-2.43,;57.3,-1.09,;59.61,-2.43,;60.37,-3.78,;61.91,-3.78,;59.6,-5.11,;57.98,-11.14,;57.96,-12.69,;59.28,-13.47,;60.63,-12.72,;60.65,-11.18,;59.32,-10.4,;61.95,-13.51,;61.93,-15.05,;63.29,-12.76,;64.62,-13.54,;65.96,-12.79,;67.35,-13.42,;68.4,-12.29,;67.64,-10.95,;66.13,-11.25,)| Show InChI InChI=1S/C31H37Cl2N7O2/c1-5-6-25(19-7-9-20(10-8-19)28(41)34-18-26-36-38-39-37-26)40-29(42)27(21-15-23(32)17-24(33)16-21)35-31(40)13-11-22(12-14-31)30(2,3)4/h7-10,15-17,22,25H,5-6,11-14,18H2,1-4H3,(H,34,41)(H,36,37,38,39)/t22-,25-,31-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-stimulated cAMP production preincubated for 30 mins follo... |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this Ligand-Target Pair | |
Glucagon receptor
(Mus musculus) | BDBM50007211
(CHEMBL3237923)Show SMILES CCC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:12.16,3.2,wD:9.10,c:7,(54.02,-13.47,;55.35,-12.68,;55.33,-11.14,;56.65,-10.36,;56.6,-8.82,;57.81,-7.87,;59.29,-8.29,;57.28,-6.42,;55.73,-6.48,;55.32,-7.96,;54.13,-6.98,;52.69,-7.51,;52.42,-9.02,;53.61,-10.01,;55.06,-9.48,;50.98,-9.56,;49.8,-8.57,;49.54,-10.09,;50.72,-11.07,;58.05,-5.09,;57.29,-3.76,;58.07,-2.43,;57.3,-1.09,;59.61,-2.43,;60.37,-3.78,;61.91,-3.78,;59.6,-5.11,;57.98,-11.14,;57.96,-12.69,;59.28,-13.47,;60.63,-12.72,;60.65,-11.18,;59.32,-10.4,;61.95,-13.51,;61.93,-15.05,;63.29,-12.76,;64.62,-13.54,;65.96,-12.79,;67.35,-13.42,;68.4,-12.29,;67.64,-10.95,;66.13,-11.25,)| Show InChI InChI=1S/C31H37Cl2N7O2/c1-5-6-25(19-7-9-20(10-8-19)28(41)34-18-26-36-38-39-37-26)40-29(42)27(21-15-23(32)17-24(33)16-21)35-31(40)13-11-22(12-14-31)30(2,3)4/h7-10,15-17,22,25H,5-6,11-14,18H2,1-4H3,(H,34,41)(H,36,37,38,39)/t22-,25-,31-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this Ligand-Target Pair | |