BDBM50008172 4-(8-Aza-spiro[4.5]dec-8-ylcarbamoyl)-4-(3,5-dichloro-benzoylamino)-butyric acid::CHEMBL340413
SMILES: OC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1
InChI Key: InChIKey=COZGZMCLUAHPHG-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CCKBR (RAT) | BDBM50008172 (4-(8-Aza-spiro[4.5]dec-8-ylcarbamoyl)-4-(3,5-dichl...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Rotta Research Laboratorium Curated by ChEMBL | Assay Description Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex | J Med Chem 35: 28-38 (1992) BindingDB Entry DOI: 10.7270/Q2XS5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholecystokinin receptor (RAT) | BDBM50008172 (4-(8-Aza-spiro[4.5]dec-8-ylcarbamoyl)-4-(3,5-dichl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.35E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rotta Research Laboratorium Curated by ChEMBL | Assay Description Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini | J Med Chem 35: 28-38 (1992) BindingDB Entry DOI: 10.7270/Q2XS5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholecystokinin receptor (Homo sapiens (Human)) | BDBM50008172 (4-(8-Aza-spiro[4.5]dec-8-ylcarbamoyl)-4-(3,5-dichl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Rotta Research Laboratorium Curated by ChEMBL | Assay Description Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric gland | J Med Chem 35: 28-38 (1992) BindingDB Entry DOI: 10.7270/Q2XS5W11 | |||||||||||
More data for this Ligand-Target Pair |