BindingDB PrimarySearch

BDBM50008434 5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid::CHEMBL140459

SMILES: CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O

InChI Key: InChIKey=SGMZGZICZKFASN-KZUDCZAMSA-N

Data: 8 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50008434
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Aminopeptidase B (Rattus norvegicus)	BDBM50008434 (5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid \| CH...) Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Competitive inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver; Ki value reporting the slope effect(Kis)				J Med Chem 32: 1378-92 (1989) BindingDB Entry DOI: 10.7270/Q20G3KQ1
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase B (Homo sapiens (Human))	BDBM50008434 (5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid \| CH...) Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Compound was tested for binding affinity towards arginyl aminopeptidase				J Med Chem 35: 451-6 (1992) BindingDB Entry DOI: 10.7270/Q2CR5SBH
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Aspartyl aminopeptidase (Homo sapiens (Human))	BDBM50008434 (5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid \| CH...) Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.70E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Compound was tested for binding affinity towards cytosolic aminopeptidase				J Med Chem 35: 451-6 (1992) BindingDB Entry DOI: 10.7270/Q2CR5SBH
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Leucyl-cystinyl aminopeptidase (Rattus norvegicus)	BDBM50008434 (5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid \| CH...) Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.70E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Competitive inhibition of leucine aminopeptidase; Ki value reporting the slope effect(Kis)				J Med Chem 32: 1378-92 (1989) BindingDB Entry DOI: 10.7270/Q20G3KQ1
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Cystinyl aminopeptidase (Rattus norvegicus)	BDBM50008434 (5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid \| CH...) Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7.90E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Non-competitive inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the slope effect(Kis)				J Med Chem 32: 1378-92 (1989) BindingDB Entry DOI: 10.7270/Q20G3KQ1
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Homo sapiens (Human))	BDBM50008434 (5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid \| CH...) Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7.90E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Compound was tested for binding affinity towards microsomal aminopeptidase; Kis was reported				J Med Chem 35: 451-6 (1992) BindingDB Entry DOI: 10.7270/Q2CR5SBH
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Cystinyl aminopeptidase (Rattus norvegicus)	BDBM50008434 (5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid \| CH...) Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.60E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Inhibition of leucine aminopeptidase				J Med Chem 32: 1378-92 (1989) BindingDB Entry DOI: 10.7270/Q20G3KQ1
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase (Homo sapiens (Human))	BDBM50008434 (5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid \| CH...) Show SMILES CC(C)C[C@H](N)C(=O)CC(Cc1ccccc1)C(O)=O Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.60E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Compound was tested for binding affinity towards microsomal aminopeptidase; Kis was reported				J Med Chem 35: 451-6 (1992) BindingDB Entry DOI: 10.7270/Q2CR5SBH
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair