BDBM50008460 CHEMBL143387::{3-[2-(2-Fluoro-phenyl)-thiazol-4-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid

SMILES: OC(=O)Cc1nn(Cc2csc(n2)-c2ccccc2F)c(=O)c2ccccc12

InChI Key: InChIKey=CKFALBKFAWADSG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50008460   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldo-keto reductase family 1 member B1 (Homo sapiens (Human))	BDBM50008460 (CHEMBL143387 | {3-[2-(2-Fluoro-phenyl)-thiazol-4-y...) Show SMILES OC(=O)Cc1nn(Cc2csc(n2)-c2ccccc2F)c(=O)c2ccccc12 Show InChI InChI=1S/C20H14FN3O3S/c21-16-8-4-3-7-15(16)19-22-12(11-28-19)10-24-20(27)14-6-2-1-5-13(14)17(23-24)9-18(25)26/h1-8,11H,9-10H2,(H,25,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description In vitro inhibitory activity against aldose reductase isolated from human placenta				J Med Chem 35: 457-65 (1992) BindingDB Entry DOI: 10.7270/Q28051K1
					More data for this Ligand-Target Pair