BDBM50008490 CHEMBL357074::{3-[(2-Chloro-phenylcarbamoyl)-methyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid

SMILES: OC(=O)Cc1nn(CC(=O)Nc2ccccc2Cl)c(=O)c2ccccc12

InChI Key: InChIKey=LVVPXSUJCOOKAD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50008490   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldose reductase (AR) (Homo sapiens (Human))	BDBM50008490 (CHEMBL357074 | {3-[(2-Chloro-phenylcarbamoyl)-meth...) Show SMILES OC(=O)Cc1nn(CC(=O)Nc2ccccc2Cl)c(=O)c2ccccc12 Show InChI InChI=1S/C18H14ClN3O4/c19-13-7-3-4-8-14(13)20-16(23)10-22-18(26)12-6-2-1-5-11(12)15(21-22)9-17(24)25/h1-8H,9-10H2,(H,20,23)(H,24,25)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description In vitro inhibitory activity against aldose reductase isolated from human placenta				J Med Chem 35: 457-65 (1992) BindingDB Entry DOI: 10.7270/Q28051K1
					More data for this Ligand-Target Pair